Skip to Main Content

Retail Pharmacies and Home Infusion Pharmacy

Avera McKennan Hospital & University Health Center offers five full-service retail pharmacies.

For your convenience, an automated phone system allows you to call and refill your prescription without talking to the pharmacist. Just have your prescription number ready and choose to pick up your prescription or have it mailed to you. Our pharmacies have computerized profiles to make sure you receive the correct prescriptions and services. We accept most prescription plans and Medicare part D plans.

These pharmacies have some unique benefits:

  • Refills mailed to you with FREE postage
  • Same insurance co-pay as other pharmacies
  • $4/$10 generic program
  • Receive a $10 gift card when you transfer your first prescription

Avera employees only:

  • Ability to pay with badge/payroll deduction
  • 10% discount on over the counter products

Avera McKennan Hospital Central Pharmacy Tour


Take a tour of the Avera McKennan Hospital Central Pharmacy with Tom Johnson, Assistant Vice President of Hospital Pharmacy.

Pharmacy Residency Program

We also offer both pharmacy practice residency and critical care pharmacy residency programs for potential pharmacy residents. Learn about our Pharmacy Residency Program »

Pharmacy Locations


Avera McKennan Hospital & University Health Center Campus Pharmacy

Avera McKennan Campus Pharmacy is located in the skywalk near the entrance to the hospital and specializes in discharged patient prescriptions, employee prescriptions and works to provide Prince of Peace and the Dougherty Hospice House with their resident medications.

  • Hours: Monday-Friday 8:00 a.m.-5:30 p.m.
  • Address: 1325 S Cliff Ave, Suite CP
  • Phone: 605-322-8326 or 800-568-6579


The inpatient pharmacy operates 24 hours a day, seven days a week. Pharmacist responsibilities include preparing and dispensing medications for hospital inpatients while also servicing several outpatient areas and clinics. This pharmacy also provides supportive services in off hours to Avera Prince of Peace and the Dougherty Hospice House. Medication orders are received in the pharmacy once verified by our pharmacist staff. About 2,000 orders are verified daily.

Plaza 2

Located on the ground level of Plaza 2 with convenient parking outside the front entrance.

Avera Specialty Pharmacy

This pharmacy offers personalized care for not only specialty patients but any retail medication that you may need. Our services are specifically designed for chronic care patients requiring high cost, life supporting medications that are not always available to local pharmacies. We also offer over-the-counter medications, high quality nutraceuticals, and zostavax vaccinations at this location.

Learn more about Avera Specialty Pharmacy

Avera Compounding Pharmacy

Backed by a name you can trust, the Avera Compounding Pharmacy employs pharmacists specially-trained to fill your prescription, compounded especially for your needs, at the highest quality. Our designation as a PCAB Accredited™ compounding pharmacy lets the public know that Avera Compounding Pharmacy ranks among the best for quality and safety. Compounded prescriptions cannot be filled at your typical drugstore, but require a specially-trained pharmacist, working within a specialized, quality-controlled environment. We also offer women’s health consultations, high quality nutraceuticals, and have a state of the art compounding lab. * Avera Compounding Pharmacy is the recipient of the Pharmacy Compounding Accreditation Board’s Seal of Accreditation since 2010.

  • Hours: Monday-Friday 9:00 a.m.–5:30 p.m.
  • Address: 1301 S Cliff Ave, Suite 225
  • Phone: 605-322-3940 or 1-866-828-7467


Avera Dermatology

Located in the Avera Medical Group Dermatology clinic, Avera Dermatology Pharmacy offers a convenient southern Sioux Falls pharmacy location. They also stock over-the-counter medications commonly recommended by the physicians but can be used for all your prescription needs not just dermatologic.

  • Hours: Monday-Friday 8:00 a.m.–4:30 p.m.
  • Address: 6701 S. Minnesota Ave
  • Phone: 605-322-7695 or 1-888-281-3923

69th Street

Avera 69th Street Pharmacy - Behavioral Health Center

This pharmacy is open to the public and has a special understanding of psychiatric medications and the issues that are unique to psychiatric illnesses. Upon your request, we offer friendly refill reminders. Let us worry about when your medications are due! Our retail area includes over-the-counter medications, high quality nutraceuticals, snacks, magazines, greeting cards, postage stamps, Avera Wear and Wyndmere aromatherapy.

Home Infusion

Home Infusion Pharmacy

Home Infusion Therapy is an emerging trend in healthcare. This cost-effective alternative to hospital-based care offers comfort and convenience for the patient at home.

Comprehensive Home Infusion therapies include:

  • Total Parenteral Nutrition
  • IV Antibiotic/Antifungal Therapy
  • Continuous IV Chemotherapy
  • Pain Management Therapy
  • Immune Globulin Therapy
  • IV Hydration
  • IV Catheter Care
  • RSV Prophylaxis Program
  • Other Specialty Injectables

We offer complete coordination of patient care, supplies and service support. Other services include:

  • Introduction call from the Home Infusion Nurse Coordinator
  • Individualized patient and family training
  • Pre-discharge conference
  • Customized pharmacy compounding
  • Dependable home delivery of supplies
  • Routine monitoring of your progress
  • Reimbursement services
  • 24-hour availability
  • Clinical feedback to your physician and Home Health nurse

Contact Home Infusion

  • Avera McKennan Home Infusion is located at 1020 S. Cliff Avenue in Sioux Falls.
  • Business hours are Monday – Friday 8 a.m. – 5 p.m.
  • Home Infusion Phone: 605-322-8322 or toll free 888-346-8085.

We have a staff member available to answer questions 24/7.